VEGF164 is a growth factor crucial for angiogenesis, vasculogenesis, and endothelial cell growth, orchestrating cellular responses vital for vascular development. It stimulates endothelial cell proliferation, facilitates cell migration, prevents apoptosis, and enhances blood vessel permeability by binding to receptors like FLT1/VEGFR1 and KDR/VEGFR2. This homodimer also plays a role in lactation and motor neuron axon guidance, showcasing its multifaceted molecular interactions.
- Stimulates endothelial cell proliferation and migration
- Prevents apoptosis and enhances blood vessel permeability
- Binds to FLT1/VEGFR1 and KDR/VEGFR2 receptors
- Exists as a disulfide-linked homodimer
- Supplied as a 0.22 μm filtered solution (100 mM Glycine, 10 mM NaCl, pH 7.0)
- Endotoxin level is less than 1 EU/μg
- Stable for 1 year at -80°C and 3 months at -20°C after opening